🧠 Polycystic Kidney Disease (PKD) — Exam Review 1. Types • Autosomal Dominant PKD (ADPKD) → most common (adult onset) • Genes: PKD1, PKD2 mutations • Symptoms appear in 30s–40s • Autosomal Recessive PKD (ARPKD) → rare, severe (childhood onset) 2. Pathophysiology • Cysts form in both kidneys → progressive enlargement → impaired kidney function • Eventually leads to chronic kidney disease (CKD) and ESRD • Also involves extrarenal cysts (liver, pancreas, spleen) 3. Clinical Features • Flank pain,