Lola on Instagram: "🎬 Fun Fact: Grey’s Anatomy (2005 - ) The iconic scene where Meredith Grey and Derek Shepherd confront each other about their complicated relationship was one of the series’ most emotionally charged moments. While the script provided the dialogue, the on-screen chemistry between Ellen Pompeo and Patrick Dempsey elevated the scene with unscripted, natural reactions. The raw emotion, particularly in Derek’s final lines, was largely a result of improvisation by Patrick Dempsey.