Pat Kelsey's Louisville Cardinals fell to Tom Izzo's Michigan State Spartans in the NCAA Tournament second round, ending UofL basketball's season.

The Louisville Cardinals and Michigan State Spartans meet Saturday in a second-round NCAA Tournament game. Tip in Buffalo, New York, is 2:45 p.m. ET.

Michigan State and Louisville meet in the Round of 32 on Saturday as teams look to advance in the 2026 NCAA Tournament.

Mr. March' (aka Tom Izzo) led Michigan State Spartans to another Sweet 16. Jeremy Fears Jr. and Coen Carr led MSU past Louisville.

No. 6 seed Louisville entered its NCAA tournament second-round matchup against No. 3 Michigan State Saturday at a significant disadvantage without injured All-ACC guard Mikel Brown Jr. That disadvantage proved too much to overcome against a tough and tournament-tested Michigan State team as the Spartans pulled away for a 77-69 win to advance to

Michigan State has advanced to the Sweet 16 for the 17th time under Tom Izzo, beating Louisville in the second round of the NCAA Tournament.

The Spartans crush the Cardinals inside in our Louisville vs. Michigan State predictions, odds and March Madness picks for March 21.

Louisville will lock horns with Michigan State in a college basketball matchup on Saturday. Here's how things have changed following the latest odds update.

The highlights plus team & player notes from the Cardinals' loss to the Spartans.