With reports of the first human death from bird flu in the US, some Americans are feeling an uncomfortable flashback to the early days of Covid-19, when infectious disease experts were talking about a new virus that was sending people to the hospital with respiratory infections.

Louisiana has reported the first U.S. fatality from avian influenza. Most of the country’s human cases have been mild

The case in Louisiana is the first human death from bird flu in the U.S. during this current outbreak, but there was a death in Mexico back in May 2024 in a patient with no known exposure to farm animals. The case, much like the patient in Louisiana, was in a person with other underlying conditions, though it’s not clear what those may have been.

In its announcement this week of the first human death from bird flu in the United States, health officials in Louisiana were quick to note that the patient was over age 65 and “reported to have underlying medical conditions.

Any time a person catches H5N1, or bird flu, their infection is a chance for the virus to mutate in the wrong direction. When someone dies from the bird flu—as an elderly Louisiana man did on Jan. 6,

The CDC says the risk of bird flu to the general public is low, but public health experts say they are worried the virus could mutate and become more transmissible.

Moderna surged as investors turned eyed potential demand for a vaccine to protect against bird flu after the US reported its first death from the virus.