New cancer drugs must be thoroughly tested in preclinical models, often in mice, before they can be offered to cancer patients for the first time in phase I clinical trials. Key components of this ...

A new mathematical model that uses drug-target kinetics to predict how drugs work in vivo may provide a foundation to improve drug discovery, which is frequently hampered by the inability to predict ...

Consider a clinical trial composed of n participants used for a pharmacological GWAS, in which each of the participants is genotyped for SNPs throughout the entire genome. These participants receive ...

Monitoring effects of imatinib (Ima) plus gemcitabine (Ge) chemotherapy (CT) on functional status of tumors (T) using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and magnetic ...

Pharmacokinetics (PK) and pharmacodynamics (PD) of E7820-an oral sulfonamide with novel, alpha-2 integrin mediated antiangiogenic properties: Results of a phase I study No significant financial ...

Pharmacodynamic effects in the human brain and energy metabolism biomarker data presented at AAIC support further clinical development of VNA-318 ...

A new comparison of four different methodologies for pharmacokinetic and pharmacodynamic testing of the anti-melanoma agent carboplatin, demonstrates that genetically-engineered mouse models provide ...