The drug's action is linked to its ability to block NMDA receptors, reducing neuronal excitability. Additionally, ketamine's antidepressant effects may involve the activation of AMPA receptors and ...

However, previous studies involving peripheral injection of excitatory amino acids have also found that NMDA or AMPA receptor antagonists completely eliminate glutamate-induced hypersensitivity 37,38.

Introduction Major depressive disorder (MDD) is a leading cause of disability worldwide, with a significant proportion of patients (10-20%) progressing to treatment-resistant depression (TRD). TRD is ...

However, this is only part of the synaptic sleep loss response. We report increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2-3. Silent synapses are absent, decreasing the ...

This fundamental study reports the effects of the psychedelic drug psilocin on iPSC-derived human cortical neurons, analyzing different aspects of structural and functional neuronal plasticity. The ...

N-methyl-D-aspartate (NMDA) receptors are critical for higher-order nervous system function, but in previously published protocols to convert human induced pluripotent stem cells (iPSCs) to mature ...

Taipei AMPA, one of Asia’s largest automotive trade shows, will return this April 23-26, 2025, at the Taipei Nangang Exhibition Centre. The show this year is presented by the Taiwan External Trade ...

15 16 20 50 The hippocampus is recognised to be particularly vulnerable to anti-NMDAR antibodies, as it possesses the highest density of NMDA receptors within the brain. Our analyses show that the ...

The Minister of Roads and Highways, Kwame Governs Agbodza, has ordered for the closure of a ‘death trap’ bridge in the Ashanti Region that recently went viral on social media. A viral video from last ...