Mayweather, turning 49 this year, comes out of a nine-year retirement to face Pacquiao, who returned to the ring last year after a four-year hiatus.
Press Secretary Karoline Leavitt said Washington has stepped up cooperation with Mexico while also demanding stronger action against organized crime.
The updated advisory cites improving conditions in northern Mexico, though U.S. staff in Tijuana remain under nighttime curfew.
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