Iran has launched retaliatory missile strikes on Israel into Saturday morning after a series of blistering Israeli attacks on the heart of Iran’s nuclear program and its armed forces, killing at least three people and wounding dozens.

Israeli emergency services have said at least two people were killed in the strikes and dozens of people are injured.

The State Department told regional allies about Israel's plan to strike Iran, and indicated it wasn't a U.S. operation, four sources told CBS News.

Israel’s sweeping attack across Iran struck at the heart of Tehran’s nuclear program, delivering a blow to the country’s ability to enrich uranium and potentially setting its nuclear ambitions back by months or years.

Iran’s most important nuclear sites at Natanz and Fordow have escaped significant damage from Israeli strikes, according to reports and satellite imagery.

Interviews with half a dozen senior Iranian officials show that they were not expecting Israel to strike before another round of talks.