The guest list echoes that of Mulaney’s previous talk show experiment on Netflix – Everybody’s in LA, which debuted last year around the Netflix is a Joke Festival.

"We will never be relevant. We will never be your source for news. We will always be reckless," Mulaney says of his new late-night Netflix show

"Everybody's Live with John Mulaney" will kick off its first show with guest appearances from Michael Keaton, Joan Baez and Fred Armisen.

Everybody may no longer be in L.A., but it’s clear that Everybody’s Live with John Mulaney, the comedian’s new weekly live Netflix talk show, will indeed be a spiritual continuation of Everybody's in LA, the experimental series he hosted during last year’s Netflix Is a Joke Fest.

Everybody’s Live with John Mulaney debuts on March 12th. Netflix is diving deeper into live content with a new late-night talk show hosted by comedian John Mulaney. Starting March 12th, Netflix will air Everybody’s Live with John Mulaney every Wednesday at 10PM ET.

Set for Wednesday, March 12th, Netflix's Everybody’s Live with John Mulaney opener includes Michael Keaton, Cypress Hill, and others.

The Emmy Award-winning comedian and former "SNL" writer John Mulaney became a superstar as a stand-up. And now, he's sitting down, as host of a talk show on Netflix. He talks with correspondent Tracy Smith about "Everybody's Live with John Mulaney.