This fundamental study reports the effects of the psychedelic drug psilocin on iPSC-derived human cortical neurons, analyzing different aspects of structural and functional neuronal plasticity. The ...

Introduction Major depressive disorder (MDD) is a leading cause of disability worldwide, with a significant proportion of patients (10-20%) progressing to treatment-resistant depression (TRD). TRD is ...

The drug's action is linked to its ability to block NMDA receptors, reducing neuronal excitability. Additionally, ketamine's antidepressant effects may involve the activation of AMPA receptors and ...