The drug's action is linked to its ability to block NMDA receptors, reducing neuronal excitability. Additionally, ketamine's antidepressant effects may involve the activation of AMPA receptors and ...

Introduction Major depressive disorder (MDD) is a leading cause of disability worldwide, with a significant proportion of patients (10-20%) progressing to treatment-resistant depression (TRD). TRD is ...

This manuscript focuses in particular on AMPA/NMDA ratios. An interesting, although speculative, aspect of the manuscript is the inclusion of a model for the accumulation of sleep needs that is based ...

However, this is only part of the synaptic sleep loss response. We report increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2-3. Silent synapses are absent, decreasing the ...

we examined the role of non-NMDA AMPA/kainate receptors in mediating glutamatergic cortical inputs to the BG. We injected CNQX, an AMPA/kainate receptor antagonist (3.0 mg/kg) at 9:00–10:00 AM in five ...

Viral vectors expressing proneural genes can stimulate adult mammalian retinal glia to become immature neurons. These glia-derived neurons share properties with the bipolar, amacrine and retinal ...

Various receptors implicated in the increase of nerve firing in the periphery or in the dorsal horn have been isolated and targeted in preclinical studies. Some of these targets and their ...

N-methyl-D-aspartate (NMDA) receptors are critical for higher-order nervous system function, but in previously published protocols to convert human induced pluripotent stem cells (iPSCs) to mature ...