A 91-year-old man with a history of bladder carcinoma and left total knee arthroplasty was evaluated because of left knee pain. A culture of synovial fluid showed no growth. A diagnosis was made.

A 91-year-old man was admitted to the hospital with weight loss, dyspnea, and eosinophilia. An anteroposterior chest radiograph obtained 2 months earlier showed bibasilar patchy opacities. A ...

This Sounding Board announces a new FDA policy that the default requirement for FDA approvals will be one robust pivotal trial plus confirmatory evidence, rather than two trials.

A 7-year-old boy was brought to a hospital with a 3-month history of cognitive deterioration and seizures. He had contracted measles at 7 months of age while living in an area where the ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 15).

When a physician’s own incidental finding sends her down a long and winding path to find answers, she finds herself overcome with worry — but also, eventually, a new appreciation for life.

The most important attribute of patient-centered care is the active engagement of patients when fateful health care decisions must be made — when they arrive at a crossroads of medical options, where ...

A high-school wrestler presented with an itchy rash that had worsened despite topical antifungal and glucocorticoid treatment. A circular, scaly plaque with papules, nodules, and pustules was seen ...

Explore this issue of The New England Journal of Medicine (Vol. 390 No. 1).

In the management of breast cancer, treatment approaches are locoregional (i.e., surgery and radiotherapy) or systemic (i.e., chemotherapy, targeted therapy, endocrine therapy, and immunotherapy). The ...

Exercise rehabilitation has a long history in the management of chronic heart failure, with the first randomized trial of exercise training dating back to 1990 1 — and by the late 1990s, it had become ...