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Thorax8d

Multimodality curative-intent treatment in NSCLC: an unprecedented era of change 2017–2025

Curative-intent multimodality treatment—combining local treatments such as surgery or radiotherapy with systemic therapy—is ...
Thorax4d

Real-world effectiveness and safety of nirsevimab, RSV maternal vaccine and RSV vaccines for older adults: a living systematic review and meta-analysis

Background The long-acting monoclonal antibody nirsevimab and respiratory syncytial virus (RSV) vaccines became available for prevention of severe RSV-associated disease in 2023. While clinical trials ...
Thorax9d

Paternal prepubertal passive smoke exposure is related to impaired lung function trajectories from childhood to middle age in their offspring

Introduction Paternal prepubertal passive smoke exposure may increase the risk of childhood asthma. However, its association ...
Thorax4d

Acute breathlessness as a cause of hospitalisation in Malawi: a prospective, patient-centred study to evaluate causes and outcomes

Introduction Breathlessness is a common cause of hospital admission globally and is associated with high mortality, ...
Thorax9d

Spirometry thresholds for clinical trial eligibility: time for urgent re-evaluation

A common eligibility criterion in respiratory clinical trials is a per cent-predicted forced expiratory volume in 1 second ...
thorax.bmj10d

Impact of regional asthma guidelines on SABA prescribing patterns across England: an interrupted time series analysis

The 2024 British Thoracic Society/ National Institute for Health and Care Excellence/ Scottish Intercollegiate Guidelines Network asthma guidelines recommend anti-inflammatory reliever (AIR)-based ...
thorax.bmj4d

Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial

1 Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium 2 Department of Respiratory Medicine, OLV Ziekenhuis, Aalst, Belgium 3 Department of Respiratory Medicine, AZ Groeninge, ...
thorax.bmj3d

Reduced treatment response to inhaled corticosteroids in current smokers with COPD, regardless of blood eosinophil count: insights from the FLAME trial

Inhaled corticosteroids (ICSs) benefit patients with chronic obstructive pulmonary disease at high risk of exacerbations with raised blood eosinophil count (BEC). Emerging evidence suggests current ...
thorax.bmj10d

Severe respiratory syncytial virus disease in preterm infants: a case of innate immaturity

Respiratory syncytial virus (RSV) is the most common viral pathogen associated with acute lower respiratory tract infection (LRTI) in children under 5 years of age. Severe RSV disease is associated ...
thorax.bmj3d

Symptoms and the early diagnosis of lung cancer

Thoracic Oncology Unit, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK Correspondence to: Dr M D Peake Thoracic Oncology Unit and Institute for Lung Health, Department of ...
thorax.bmj4d

Integrated breathing and relaxation training (the Papworth method) for adults with asthma in primary care: a randomised controlled trial

Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK Elizabeth Holloway, Research Physiotherapist, Department of Epidemiology and Public ...
thorax.bmj22y

Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study

5 Division of Respiratory Medicine, Nottingham City Hospital, Nottingham NG5 1PB, UK Correspondence to: Dr J T Macfarlane, Respiratory Infection Research Group, Respiratory Medicine, Nottingham City ...