Surface-exposed calreticulin (ecto-CRT) is a well-known “eat-me” signal exhibited by dying cells that contributes to their recognition and destruction by the immune system. We assessed the use of a ...
Identifying cancer therapy resistance is a key time-saving tool for physicians. Part of chemotherapy resistance includes senescence, a persistent state without cell division or cell death. Chemically ...
Immune checkpoint blockade (ICB) has achieved groundbreaking results in clinical cancer therapy; however, only a subset of patients experience durable benefits. The aim of this study was to explore ...
Journal of Nuclear Medicine August 2025, jnumed.125.269671; DOI: https://doi.org/10.2967/jnumed.125.269671 ...
Interleukin-13 receptor α-2 (IL13Rα2) is a cell surface receptor frequently expressed in solid malignancies, such as glioblastoma and melanoma, with limited expression in healthy tissue, rendering it ...
C-X-C motif chemokine receptor 4 (CXCR4) is a transmembrane chemokine receptor involved in various biologic processes, including tumor growth, metastasis, and the homing and retention of hematopoietic ...
Prostate-specific membrane antigen (PSMA) PET/CT is widely used to monitor response during [177Lu]Lu-PSMA radiopharmaceutical therapy (RPT) in metastatic castration-resistant prostate cancer (mCRPC), ...
The management of prostate cancer increasingly relies on androgen axis–targeted therapies, such as enzalutamide, which is now administered progressively earlier and for longer durations ( [1] [1]).
Johannes Czernin, MD, editor in chief of The Journal of Nuclear Medicine, talked with David W. Townsend, PhD, and Thomas Beyer, PhD, MBA, about their pioneering work in the development of PET/CT ...
Journal of Nuclear Medicine March 2026, jnumed.125.271296; DOI: https://doi.org/10.2967/jnumed.125.271296 ...
Journal of Nuclear Medicine March 2026, jnumed.125.271601; DOI: https://doi.org/10.2967/jnumed.125.271601 ...
Nectin cell adhesion molecule 4 (nectin-4) is a transmembrane protein overexpressed on a variety of cancers and plays an important role in oncogenic and metastatic processes. The nectin-4–targeted ...
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