Pregame analysis and predictions of the Houston Astros vs. Athletics MLB game to be played on September 23, 2025 on ESPN.

The first 1,500 patrons to the Kane County Cougars' game will receive a Pope Leo XIV bobblehead on Thursday. The 25-year-old Baltimore Orioles left-handed starter posted on X early Saturday, revealing a disturbing screenshot of an Instagram direct message he said his wife received Friday night.

Astros center fielder Jake Meyers stood at home plate in disbelief, echoing the feeling of a sellout crowd that had just ridden a roller-coaster of emotions in the span of about 10 seconds. Nervousness turned to excitement before giving away to disappointment.

Upcoming Houston Astros game When is the next Astros game? Sunday, September 21 Who are they playing? Seattle Mariners Where

The Astros are currently two games behind the Mariners in the AL West and just a half-game ahead of the Guardians for the third WC spot.

The Seattle Mariners face the Houston Astros in a regular season MLB game on Sunday, Sept. 21, 2025 (9/21/25) at Daikin Park in Houston, Texas.

Alvarez has also proven to be a playoff riser in his career, playing a crucial part in Houston’s deep postseason runs since his MLB debut in 2019. He took home ALCS MVP in 2021 and had many memorable moments when he helped the Astros win the World Series the following year in 2022.

Preview the Sept. 24 matchup between the Houston Astros and Athletics with odds over/under, game spread, betting lines and more.

On Sunday, Peña said he injured his oblique while avoiding a tag during the sixth inning of Saturday’s 6-4 loss against Seattle. He remained in the game and, one inning later, hit a grand slam that pulled Houston within two runs.