Several methods for tissue preparation and refractive index matching to achieve rapid, even, and thorough tissue transparency have been developed. These include CUBIC 1, DISCO 2, EZClear 3, and ...

Light sheet microscopy and preparative clearing methods that improve light penetration in 3D tissues have revolutionized imaging in biomedical research. Here we present ADAPT-3D, a streamlined 3-step ...

A team led by Raju Tomer, professor of biological sciences at Columbia University, has created a new design for microscopes ...

Researchers at the University of California, Los Angeles (UCLA) have pioneered a groundbreaking approach in the imaging and detection of amyloid deposits in tissue samples. The innovative method ...

Our brain is a complex organ. Billions of nerve cells are wired in an intricate network, constantly processing signals, enabling us to recall memories or to move our bodies. Making sense of this ...

Until today, skin, brain, and all tissues of the human body were difficult to observe in detail with an optical microscope, since the contrast in the image was hindered by the high density of their ...

There is a growing demand for non-invasive insights into the complex three-dimensional subcellular dynamics within living tissues on the frontier of biological research. To achieve simultaneous ...

The researchers demonstrated the utility of their technique on a slice of a mouse brain, 200 microns (0.2 millimeters) in thickness. First, they made their tissue sample see-through using a tweaked ...

Selective plane illumination microscopy (SPIM) is a type of light sheet fluorescence microscopy (LSFM), which is one such 3D imaging technique employing a thin sheet of light to illuminate cleared ...

Freshly dissected tissue (lower left) and its pathology-prepared slide with identified tumor regions by a pathologist (upper left), and a pseudo-color image of hyperspectral dark-field microscopy ...

Researchers have developed a new microscopy technology called decrowding expansion pathology (dExPath) to analyze brain tissue. By pulling proteins apart with dExPath, researchers can stain proteins ...

Both for research and medical purposes, researchers have spent decades pushing the limits of microscopy to produce ever deeper and sharper images of brain activity, not only in the cortex but also in ...