Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

A research team has developed an innovative technique that enables precise modification of specific proteins within complex biological environments. The work was led by Professor Seung Soo Oh and Dr.

When improperly folded proteins build up in the endoplasmic reticulum (ER), cells become stressed and conditions such as type 2 diabetes, neurodegenerative disorders, and cancers can develop. In a ...

Cancer has often been explained through mutations in deoxyribonucleic acid (DNA) or changes in ribonucleic acid (RNA), but ...

Imagine riding a bike. Now imagine riding a bike with an enormous beach ball stuck on your handlebars. That "modification" might change your experience quite a bit. In our cells, molecules called ...

Researchers at Baylor College of Medicine have developed an artificial intelligence (AI) model that reveals how protein modifications link genetic mutations to disease. The method, called DeepMVP and ...

"For histones, the time window for modifications is incredibly tight because their protein chains are very short," explains first author Denis Yudin, a doctoral student in Nenad Ban's lab. "NAC ...

An AI model that reveals how protein modifications link genetic mutations to disease has been developed. Researchers at Baylor College of Medicine (TX, USA) have developed an AI model that reveals how ...

Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby regulate proteins. Malfunctioning of DUBs could lead to diseases, including ...

LA JOLLA, CA—Imagine riding a bike. Now imagine riding a bike with an enormous beach ball stuck on your handlebars. That "modification" might change your experience quite a bit. In our cells, ...