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Week 10 NFL odds, lines, best bets, predictions

Week 10 NFL odds, lines, best bets, predictions: Computer model likes Buccaneers and 49ers

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 on a sizzling 47-29 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

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NFL odds, lines, spreads: 2025 Week 10 picks, predictions from proven model

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NFL Week 10 predictions, ESPN matchup predictor's picks, win probabilities for this week

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NFL Week 10 picks, predictions, score projections for who wins every NFL game this week

Thanksgiving Day isn't until later this month, but you don't have to wait for a feast of football.

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NFL Week 10 odds, point spreads, moneylines, over/unders for betting on games this week

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2025 NFL Week 10 rushing touchdowns predictions and player prop bets

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Week 9 NFL score predictions, best bets, odds, picks today: Expert reveals exact scores for all 14 matchups

Perhaps to the surprise of some, the New England Patriots and Denver Broncos, who are both 6-2 and atop their respective divisions with second-year quarterbacks at the helm, enter Week 9 with the longest active winning streaks in the NFL.

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2025 NFL playoff predictions: Picking every division winner and wild-card team at midseason

Which eight NFL teams will be crowned division champs this season? Who'll nab the six wild-card slots? At the midpoint of the 2025 campaign, our analysts provide their playoff predictions.