They'll get the chance to avenge their latest loss in a matchup this week with the 49ers, who continue to be one of the least healthy teams in the league with another member of the defensive line lost for the season in Mykel Williams.

Sportsbooks give the Denver Broncos (7-2) a good chance to keep their six-game winning streak intact, as they are favored by 9 points in a matchup with the Las Vegas Raiders (2-6) on Thursday, November 6, 2025 at Empower Field at Mile High. The point total has been set at 42.5.

The Bills are the new class of the NFL, according to DraftKings Sportsbook oddsmakers. After beating the Chiefs 28-21 on Sunday, Buffalo took over for Kansas City as the Super Bowl favorites, sitting at +600 heading into Week 10. The Chiefs aren’t far behind with +650 odds.

Week 8 of the 2025 NFL season was a historic one for betting favorites, as they went 11-2 against the spread to tie the best ATS mark for favorites in any one week since the 1970 AFL/NFL merger. In Week 9, the underdogs got their revenge in a big way.

Seattle vs. Washington takes place on Sunday Night Football, and bettors can use NFL sportsbook promos on the best NFL betting sites and NFL betting apps

In the wake of the NBA scandal, our business of football analyst looks back at when fantasy football was frowned on and the Raiders moved to Las Vegas.

Sunday, the Detroit Lions (5-3) look to get back on the winning track when they travel to our nation’s capital to take on the Washington Commanders (3-6). Heavily favored Jared Goff and co. look to take advantage of a Commanders’ squad minus its QB1, Jayden Daniels.