ascopubs.org

Bayesian Adaptive Randomization: Full of Promise With a Helping of Caution

Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits In the article that accompanies this ...
Nature

Identification of an optimal dose of intravenous ketamine for late-life treatment-resistant depression: a Bayesian adaptive randomization trial

Monoaminergic drugs are considered first-line treatment for major depressive disorder (MDD) but can take eight weeks or longer to achieve a response (defined as ≥50% symptom improvement) [1]. Symptom ...
EurekAlert!

Revolutionizing clinical trials with machine learning

Professor Yeonhee Park of the Department of Statistics at Sungkyunkwan University has developed a novel statistical framework — MARGO (Machine Learning-Assisted Adaptive Randomization for Group ...
Nature

Androgen receptor pathway inhibitors and taxanes in metastatic prostate cancer: an outcome-adaptive randomized platform trial

Metastatic castration-resistant prostate cancer (mCRPC) is a genetically and clinically heterogeneous disease that can be treated with different classes of systemic agents, such as androgen receptor ...
ascopubs.org

Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma

Susan G. Komen Big Data for Breast Cancer Initiative: How Patient Advocacy Organizations Can Facilitate Using Big Data to Improve Patient Outcomes Adequately prioritizing the numerous therapies and ...