Observational studies have linked adiposity and especially abdominal adiposity to liver fat accumulation and non-alcoholic fatty liver disease. These traits are also associated with type 2 diabetes ...

Increasing evidence indicates a role for inflammation, the tissue response to potentially harmful stimuli, in the pathogenesis of mental health disorders, particularly depression 1,2. Even though, ...

The schematic illustrates the comprehensive pipeline for Mendelian randomization analysis, starting with multi-omics data inputs from GWAS, eQTL, and pQTL studies, sourced from major databases such as ...

Mendelian randomization, a powerful tool in medical research, helps us understand whether certain factors truly cause disease. This technique uses genetic variations as "natural experiments" to reveal ...

A groundbreaking new book – the first of its kind in Chinese – is now available to empower researchers with the powerful tool of Mendelian randomization. Translated from the esteemed text "Mendelian ...

Researchers at Columbia University Mailman School of Public Health have developed a novel computational pipeline designed to identify protein biomarkers associated with complex diseases, including ...

For decades, many people believed moderate drinking—especially red wine—could be good for the heart. New research is ...

Using MR-SPI and AlphaFold3, scientists unravel the molecular underpinnings of Alzheimer’s disease, identifying key protein changes that could reshape future treatments. Study: Deciphering proteins in ...