Nature

Glucose-driven intra- and inter-islet beta cell synchronization in pancreatic tissue slices

Coordinated insulin secretion by the numerous islets dispersed throughout the pancreas generates the characteristic pulsatility of circulating insulin, which optimizes peripheral insulin action. While ...
Nature

Platform design of hybrid microphysiological system integrating in vitro and in silico models for reproducing insulin-regulated glucose metabolism

This study presents a hybrid platform for microphysiological systems (MPS) that combines in vitro organ-on-a-chip (OoC) technology and an in silico model. In this platform, in silico models act as ...
Phys.org

Mitochondria migrate toward the cell membrane in response to high glucose levels, study shows

Unlike our organs, cell organelles such as mitochondria are not fixed in place, but when, where, how, and why organelles move remain unclear. Research published in the Biophysical Journal shows that ...
News Medical

Mitochondria shift toward the cell edge in response to glucose

Unlike our organs, cell organelles such as mitochondria are not fixed in place, but when, where, how, and why organelles move remain unclear. Research publishing December 18 in the Cell Press journal ...