Newborn nerve cells must squeeze through crowded, narrow spaces—through dense tissue, past other cells, and between fibers—to ...

Migrating newborn neurons suffer routine double-strand DNA breaks from physical stress during brain development.

p53-mediated cell cycle arrest during DNA damage is dependent on the induction of p21 protein, encoded by the CDKN1A gene. p21 inhibits cyclin-dependent kinases required for cell cycle progression to ...

RNA Polymerase (shown in blue) moves across a template strand of DNA (shown in purple) and transcribes it into RNA (shown in red). But DNA damage blocks the RNA polymerase, causing it to stall and ...

Scientists have discovered that a gene normally considered a DNA-protecting "good guy" can become dangerous when cells make too much of it. The gene, EXO1, acts like molecular scissors that help ...

Cancer cells often survive treatment by fixing the DNA damage that therapy is meant to cause. Researchers found that UNI418 ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Similar to the way DNA damage can contribute to human diseases such as cancer, it can also disrupt growth, development and ...