Nature

Coding polymorphisms in CD33 and response to gemtuzumab ozogamicin in pediatric patients with AML: a pilot study

After binding to the CD33 antigen on the surface of myeloid cells, the GO–CD33 complex is internalized and calicheamicin is released. By binding to the DNA minor groove in a sequence-specific manner, ...
ascopubs.org

A polymorphism in the coding sequence of WT1 is an independent prognostic marker in 1,101 patients with lobular breast cancer.

Clinical relevance of mesenchymal stem cell–induced resistance to chemotherapy. This is an ASCO Meeting Abstract from the 2011 ASCO Annual Meeting I. This abstract does not include a full text ...
Nature

Efficient discovery of single-nucleotide polymorphisms in coding regions of human genes

Most high-throughput SNP discovery has been from bulk genomic sequence. However, because coding regions constitute only a small fraction of the human genome, the fraction of these data that are cSNPs ...
ascopubs.org

CD33 Splicing Polymorphism Determines Gemtuzumab Ozogamicin Response in De Novo Acute Myeloid Leukemia: Report From Randomized Phase III Children’s Oncology Group Trial AAML0531

Participant-Reported Symptoms and Their Effect on Long-Term Adherence in the International Breast Cancer Intervention Study I (IBIS I) CD33 splicing single nucleotide polymorphism was evaluated in ...